2-(1H-1,2,4-Triazol-1-yl)-2′,4′-Difluoroacetophenone CAS 86404-63-9 Voriconazole Intermediate Purity >98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 2-(1H-1,2,4-Triazol-1-yl)-2',4'-Difluoroacetophenone (CAS: 86404-63-9) with high quality, intermediate of Voriconazole (CAS: 137234-62-9). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Voriconazole Intermediates, Please contact: alvin@ruifuchem.com
| Chemical Name | 2-(1H-1,2,4-Triazol-1-yl)-2',4'-Difluoroacetophenone |
| Synonyms | 2,4-Difluoro-α-(1H-1,2,4-Triazolyl)acetophenone; 2,4-Difluoro-alpha-(1H-1,2,4-Triazolyl)acetophenone; 1-(2,4-Difluorobenzoylmethyl)-1H-1,2,4-Triazole; 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-Triazol-1-yl)ethanone; 2',4'-Difluoro-2-(1H-1,2,4-Triazol-1-yl)acetophenone; 2',4'-Difluoro-alpha-(1H-1,2,4-Triazol-1-yl)acetophenone |
| Impurity | USP Voriconazole Related Compound C; Voriconazole EP Impurity A |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 86404-63-9 |
| Molecular Formula | C10H7F2N3O |
| Molecular Weight | 223.18 g/mol |
| Melting Point | 103.0~108.0℃(lit.) |
| Boiling Point | 388.0±52.0℃ |
| Density | 1.39±0.10 g/cm3 |
| COA & MSDS | Available |
| Place of Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | Light Yellow to Off-White Crystalline Powder | Light Yellow Crystalline Powder |
| Melting Point | 103.0~108.0℃ | 104.3℃ |
| Water by Karl Fischer | <0.50% | 0.2% |
| Purity / Analysis Method | >98.0% (HPLC) | 99.2% |
| Infrared Spectrum | Conforms to Structure | Conforms |
| 1H NMR Spectrum | Conforms to Structure | Conforms |
| Conclusion | The product has been tested and complies with the given specifications | |
| Application | Intermediate of Voriconazole (CAS: 137234-62-9) | |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Xn - Harmful
Risk Codes R36/37/38 - Irritating to eyes, respiratory system and skin.
R22 - Harmful if swallowed
Safety Description 24/25 - Avoid contact with skin and eyes.
WGK Germany 3
HS Code 2933990099
2-(1H-1,2,4-Triazol-1-yl)-2',4'-Difluoroacetophenone (CAS: 86404-63-9), a pharmaceutical and chemical intermediate, is used as an intermediate of Voriconazole (CAS: 137234-62-9).
Voriconazole is a broad-spectrum triazole antifungal ,it is primarily used for the treatment of progressive, possibly life-threatening infections in immune deficiency patients. Indications include: immunosuppressed patients with severe fungal infections, acute invasive aspergillosis (the most common pathogen is Aspergillus fumigatus, followed by A. flavus, Aspergillus niger and Aspergillus soil), severe invasive infections caused by fluconazole-resistant Candida (including C. krusei) severe infection caused by Foot actinomycetes bacteria genus and Fusarium bacteria genus.
